Yes, absolutely. If you wish to share a PowerPoint presentation or Acrobat document, for example, and prefer that the rest of your desktop is not visible, the first step is to make sure you have that application open before sharing your screen.
Once you have the document open that you wish to share, click the 'SHARE' icon in the menu at the top of your dashboard and select 'Application Window'. You will then have the option to choose which window or application you wish to share.
Simply click on the application with the document you wish to share with your participants and this will then be displayed in place of your video image (if you had activated your webcam prior to sharing your screen).